In _The Priority of Prudence_, Daniel Mark Nelson proposes a reappropriation of a moral perspective that focuses on the cardinal virtues of courage, temperance, justice, and prudence. The study aims to recover and rehabilitate the virtue of prudence as a way of resuming a moral conversation that has been stalemated for too long. Nelson's main source for reviving the virtue of prudence is St. Thomas Aquinas's account of the cardinal virtues in the _Summa Theologica_. A primary (...) problem with using Aquinas as a source for reviving an ethics of virtue centered on prudence is that he is commonly perceived as the most prominent figure in the conflicting natural-law tradition. According to Nelson's reinterpretation, however, Aquinas teaches that moral understanding depends first and foremost on prudence working in accord with other cardinal virtues and that natural law functions to explain moral reasoning rather than to guide it. This study serves to advance the debate about the contemporary relevance of an ethics of virtue by way of its significantly more detailed explication of prudence. Nelson makes important connections between influential reinterpretations of the ethical theory of Aquinas that have been published during the last thirty years and widespread interest in an ethics of virtue that has been expressed by Alasdair Maclntyre, Stanley Hauerwas, William Sullivan, Robert Bellah, and others. _The Priority of Prudence _represents a significant contribution to the scholarly literature both in the study of Aquinas and in the debate on the ethics of virtue. (shrink)

We are currently seeing a revival of interest in Aquinas's moral thought among Christian ethicists, both Protestant and Catholic. Although recent studies of his moral thought have touched on a number of topics, the majority of these have focused on his account of the virtues and their place in the Christian life. Probing the questions of the relation of virtue and law, the role of reason and will, and the place of the passions in Aquinas's moral theology, I will examine (...) recent studies by Diana Cates, Pamela Hall, Simon Harak, James Keenan, Daniel Nelson, Daniel Westberg, and Paul Waddell. In different ways these studies return us repeatedly to the vexed and unresolved question of the scope of human freedom. (shrink)

The overlap and differences between the parallel regulatory systems for research create ample room for confusion and missteps, as discussed by Barbara Bierer and Mark Barnes in their report in this supplement. In practice, beyond the inherent differences in the two systems of regulations themselves, there are many issues that further complicate the application of these regulations. These include the variation in size of the institutions receiving PHS funding, the increased prevalence of multisite research, the allocation of research conduct (...) and oversight to external organizations, and the variability in assignment of human subject protection roles between the IRB and the institution. (shrink)

In this paper, I investigate the merits of an argument in the philosophy of mysticism which, if sound, appears to have serious implications for our estimation of various Christian saints, mystics, and theologians and some of their most profound spiritual experiences. After giving an initial statement of this argument, I offer a defense of the two main premises at play and conclude the argument is plausibly sound. Following this, I turn to a discussion of Nelson Pike’s important objection to (...) this argument and contend that, while doubtless more interesting than commonly supposed, it ultimately falls short of the mark. (shrink)

Philosophical analyses of scientific concepts are legion. However, this literature is replete with methodological errors that have largely gone unnoticed. Five distinct projects are conflated which has led to faulty inferences, ambiguities, and mischaracterizations. There has also been some recent enthusiasm for approaches that attempt to rectify problematic scientific concepts but the motivations for these approaches are questionable. I am hopeful that by bringing these various issues to light that it will lead practitioners to be more explicit about their aims (...) and subsequently result in better analyses. (shrink)

We hypothesize that aspects of animal multicellularity originated before the divergence of metazoans from fungi and social amoebae. Polarized epithelial tissues are a defining feature of metazoans and contribute to the diversity of animal body plans. The recent finding of a polarized epithelium in the non‐metazoan social amoeba Dictyostelium discoideum demonstrates that epithelial tissue is not a unique feature of metazoans, and challenges the traditional paradigm that multicellularity evolved independently in social amoebae and metazoans. An alternative view, presented here, is (...) that the common ancestor of social amoebae, fungi, and animals spent a portion of its life cycle in a multicellular state and possessed molecular machinery necessary for forming an epithelial tissue. Some descendants of this ancestor retained multicellularity, while others reverted to unicellularity. This hypothesis makes testable predictions regarding tissue organization in close relatives of metazoans and provides a novel conceptual framework for studies of early animal evolution.Editor's suggested further reading in BioEssays Searching for Eve: Basal metazoans and the evolution of multicellular complexity Abstract. (shrink)

Recent decades have seen a shift away from the traditional view that Aquinas's theory of the natural law is meant to supply us with normative guidance grounded in a substantive theory of human nature. In the present essay, I argue that this is a mistake. Expanding on the suggestions of Jean Porter and Ralph McInerny, I defend a derivationist reading of ST I-II, Q. 94, A. 2 according to which Aquinas takes our knowledge of the genuine goods of human life (...) and their proper ordering to one another to be self-evident only to the wise who are able to discern the truth about our God-given human nature. I then show that this reading provides a better account of Aquinas's view than two recent alternatives: John Finnis's brand of inclinationism and Daniel Mark Nelson's virtue-based interpretation. (shrink)

Are there good arguments from Is to Ought? Toomas Karmo has claimed that there are trivially valid arguments from Is to Ought, but no sound ones. I call into question some key elements of Karmo’s argument for the “logical autonomy of ethics”, and show that attempts to use it as part of an overall case for moral skepticism would be self-defeating.

Since the time of Hume, many philosophers have thought it impossible to deduce an ‘Ought’ from an ‘Is,’ or in general to deduce ‘ethical sentences’ from purely ‘factual sentences.’ This is the thesis of the logical autonomy of ethics. I consider a more recent argument by Toomas Karmo in support of the autonomism, but show its limitations in the context of justification skepticism about ethics.

Presenilin‐1 (PS1) is thought to regulate cell differentiation and survival by modulating the Notch signaling pathway. Mutations in PS1 have been shown to cause early‐onset inherited forms of Alzheimer's disease (AD) by a gain‐of‐function mechanism that alters proteolytic processing of the amyloid precursor protein (APP) resulting in increased production of neurotoxic forms of amyloid β‐peptide. The present article considers a second pathogenic mode of action of PS1 mutations, a defect in cellular calcium signaling characterized by overfilling of endoplasmic reticulum (ER) (...) calcium stores and altered capacitive calcium entry; this abnormality may impair synaptic plasticity and sensitize neurons to apoptosis and excitotoxicity. The calcium signaling defect has also been documented in lymphocytes, suggesting a contribution of immune dysfunction to the pathogenesis of AD. A better understanding of the calcium signaling defect resulting from PS1 mutations may lead to the development of novel preventative and therapeutic strategies for disorders of the nervous and immune systems. BioEssays 23:733–744, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

This paper presents five studies on the development and validation of a scale of intellectual humility. This scale captures cognitive, affective, behavioral, and motivational components of the construct that have been identified by various philosophers in their conceptual analyses of intellectual humility. We find that intellectual humility has four core dimensions: Open-mindedness (versus Arrogance), Intellectual Modesty (versus Vanity), Corrigibility (versus Fragility), and Engagement (versus Boredom). These dimensions display adequate self-informant agreement, and adequate convergent, divergent, and discriminant validity. In particular, Open-mindedness (...) adds predictive power beyond the Big Six for an objective behavioral measure of intellectual humility, and Intellectual Modesty is uniquely related to Narcissism. We find that a similar factor structure emerges in Germanophone participants, giving initial evidence for the model’s cross-cultural generalizability. (shrink)

Absolutism—the idea that some kinds of acts are absolutely wrong and must never be done—plays an important role in medical ethics. Nicholas Denyer has defended it from some influential consequentialist critics who have alleged that absolutism is committed to “agent-relative constraints” and therefore intolerably complex and messy. Denyer ingeniously argues that, if there are problems with agent-relative constraints, then they are problems for consequentialism, since it contains agent-relative constraints, too. I show that, despite its ingenuity, Denyer’s argument does not succeed. (...) The defense of absolutism must move to other grounds. (shrink)

Elaine Sternberg's Just Business is one of the first book-length Aristotelian treatments of business ethics. It is Aristotelian in the sense that Sternberg begins by defining the nature of business in order to identify its end, and, thence, normative principles to regulate it. According to Sternberg, the nature of business is 'the selling of goods or services in order to maximise long-term owner value', therefore all business behaviour must be evaluated with reference to the maximisation of long-term owner value, constrained (...) only by considerations of ordinary decency and distributive justice. This stands in sharp contrast to recently popular 'stakeholder' approaches to business decision making. I argue that Sternberg's definition of business, particularly in its maximising and long-term conditions, is flawed, that her teleological method raises more questions than it solves, and that her Aristotelianism cannot be wedded happily to her libertarianism. (shrink)

Elaine Sternberg’s Just Business is one of the first book‐length Aristotelian treatments of business ethics. It is Aristotelian in the sense that Sternberg begins by defining the nature of business in order to identify its end, and, thence, normative principles to regulate it. According to Sternberg, the nature of business is ‘the selling of goods or services in order to maximise long‐term owner value’, therefore all business behaviour must be evaluated with reference to the maximisation of long‐term owner value, constrained (...) only by considerations of Ordinary decency and distributive justice. This stands in sharp contrast to recently popular ‘stakeholder’ approaches to business‐ethical decision making. I argue that Sternberg’s definition of business, particularly in its maximising and long‐term conditions, is flawed, that her teleological method raises more questions than it solves, and that her Aristotelianism cannot be wedded happily to her libertarianism. (shrink)

It is wrong to deceive people, to get them to believe falsehoods. At least some times, when I wear a wig, I attempt to deceive people about how much hair I have. Why is this not deception? Why is this not wrong? These are the questions I explore.

Walter Sinnott-Armstrong’s recent defence of moral scepticism raises the debate to a new level, but I argue that it is unsatisfactory because of problems with its assumption of global scepticism, with its use of the Sceptical Hypothesis Argument, and with its use of the idea of contrast classes and the correlative distinction between ‘everyday’ justification and ‘philosophical’ justification. I draw on Chisholm’s treatment of the Problem of the Criterion to show that my claim that I know that, e.g., baby-torture is (...) wrong, is no more question-begging than Sinnott-Armstrong’s denial that I know this. (shrink)

The Clarke/Rowe version of the Cosmological Argument is sound only if the Principle of Sufficient Reason is true, but many philosophers, including Rowe, think that there is not adequate evidence for the principle of sufficient reason. I argue that there may be indirect evidence for PSR on the grounds that if we do not accept it, we lose our best justification for an important principle of metaethics, namely, the Principle of Universalizability. To show this, I argue that all the other (...) justifications of the Principle of Universalizability on offer, including Richard Hare's, are inadequate. (shrink)

This article is not intended to state what I positively believe to be true, but to make a suggestion which I think it well-worth working out. The suggestion is not altogether unfamiliar, but it has certain implications that seem to have been so far overlooked, or at any rate have never been developed. I do not think that it is the duty of a philosopher to confine himself in his publications to working out theories of the truth of which he (...) is convinced.… It is a part of a philosopher's work, as it is of a scientist's, to try out tentative hypotheses and examine their advantages and disadvantages. (shrink)

I define ethical intuitionism as the view that it is appropriate to appeal to inferentially unsupported moral beliefs in the course of moral reasoning. I mention four common objections to this view, including the view that all such appeals to intuition make ethical theory politically and noetically conservative. I defend intuitionism from versions of this criticism expressed by R.B. Brandt, R.M. Hare and Richard Miller.

In ethics, it is commonly supposed that we have both positive duties and negative duties, things we ought to do and things we ought not to do. Given the many parallels between ethics and epistemology, we might suppose that the same is true in epistemology, and that we have both positive epistemic duties and negative epistemic duties. I argue that this is false; that is, that we have negative epistemic duties, but no positive ones. There are things that we ought (...) not to believe, but there is nothing that we ought to believe, on purely epistemic grounds. I also consider why the parallels between ethics and epistemology break down at this particular point, suggesting that it is due to what I call the infinite justificational ‘fecundity’ of perceptual and propositional evidence. (shrink)

The scientific, ethical, and policy issues raised by research involving the engraftment of human neural stem cells into the brains of nonhuman primates are explored by an interdisciplinary working group in this Policy Forum. The authors consider the possibility that this research might alter the cognitive capacities of recipient great apes and monkeys, with potential significance for their moral status.

Is it possible to have moral knowledge? ‘Moral justification skeptics’ hold it is not, because moral beliefs cannot have the sort of epistemic justification necessary for knowledge. This skeptical stance can be summed up in a single, neat argument, which includes the premise that ‘Inductive arguments from non-moral premises to moral conclusions are not possible.’ Other premises in the argument may rejected, but only at some cost. It would be noteworthy, therefore, if ‘inductive inferentialism’ about morals were shown to be (...) at least possible. Some philosophers may suppose that inductive moral arguments from non-moral premises cannot get off the ground, but I show that a perfectly legitimate inductive moral argument exists. This argument has non-moral premises and a moral conclusion, its premises are related to its conclusion in the right way, and it avoids some of the problems of other, better-known arguments from ‘Is’ to ‘Ought’. (shrink)

Debates over health care have focused for so long on economics that the proper goals for medicine seem to be taken for granted; yet problems in health care stem as much from a lack of agreement about the goals and priorities of medicine as from the way systems function. This book asks basic questions about the purposes and ends of medicine and shows that the answers have practical implications for future health care delivery, medical research, and the education of medical (...) students. The Hastings Center coordinated teams of physicians, nurses, public health experts, philosophers, theologians, politicians, health care administrators, social workers, and lawyers in fourteen countries to explore these issues. In this volume, they articulate four basic goals of medicine — prevention of disease, relief of suffering, care of the ill, and avoidance of premature death — and examine them in light of the cultural, political, and economic pressures under which medicine functions. In reporting these findings, the contributors touch on a wide range of diverse issues such as genetic technology, Chinese medicine, care of the elderly, and prevention and public health. The Goals of Medicine clearly demonstrates the importance of clarifying the purposes of medicine before attempting to change the economic and organizational systems. It warns that without such examination, any reform efforts may be fruitless. (shrink)